Chapter 4: Tumor Lysis Syndrome
نویسنده
چکیده
Tumor lysis syndrome (TLS) is a constellation of metabolic abnormalities resulting from either spontaneous or chemotherapy-induced tumor cell death. Tumor cytotoxicity releases intracellular contents, including nucleic acids, proteins, and electrolytes into the systemic circulation and may lead to development of hyperuricemia, hyperphosphatemia, hypocalcemia, andhyperkalemia.Clinically, this results in multiorgan effects such as AKI, cardiac arrhythmias, and seizures (1,2). TLS is the most common oncologic emergency (3), and without prompt recognition and early therapeutic intervention, morbidity and mortality is high.
منابع مشابه
Frequency of Tumor Lysis Syndrome in Aggressive and Slow Introduction Chemotherapy in Children with ALL
Abstract Background Tumor Lysis Syndrome (TLS) is an oncologic emergency that results from massive lysis of malignant cells. The incidence of TLS depends on the risk factors, such as baseline hyperuricemia, bulky tumor burden, elevated serum LDH, and elevated WBC. The objectives of the present study were to assess frequency of Tumor Lysis Syndrom in children with ALL in two methods of inducti...
متن کاملThe Prevalence of Tumor Lysis Syndrome in Children and Adolescents with Cancer in Hamedan Province, Iran
Background: Tumor lysis syndrome caused by widespread tumor cell damage may lead to electrolyte imbalances and express as metabolic disturbance causing clinical abnormalities. Patients and Methods: All patients younger than 16 years with documented malignancy candidate for chemotherapy, in Hamedan province of Iran were enrolled. Results: Out of 69 cancer patients the laboratory form of tumor ...
متن کاملThe Efficacy of Single Dose Rasburicase in Prevention or Treatment of Tumor Lysis Syndrome in Children
Background: Tumor lysis syndrome (TLS) is a major metabolic complication in patients with malignancy after initiation of chemotherapy or spontaneously without treatment. The role of Rasburicase (a recombinant urate-oxidase enzyme) in prevention and treatment of TLS has been demonstrated in recent years. We aimed to investigate the efficacy of a single dose of rasburicase in reducing the risk of...
متن کاملIdentification of children with acute lymphoblastic leukemia at low risk for tumor lysis syndrome
Background and Objective: Tumor lysis syndrome (TLS) could occur before, during or after the initiation of chemotherapy in patients with cancers especially those with hematologic malignancies. This study was designed to determine the prevalence and predictors of TLS in children with Acute Lymphoblastic Lymphoma (ALL) and to develop a sensitive prediction rule to identify patients at low risk of...
متن کاملAcute renal failure due to renal lymphomatous infiltration as the initial manifestation
A male patient with acute renal failure (ARF) due to large B-cell non-Hodgkin lymphoma infiltration of kidney is presented. The diagnosis was suspected because of coincidence of ARF and tumor lysis syndrome non-responsive to conservative renal therapies. A renal biopsy confirmed diagnosis and appropriate chemotherapy led to complete improvement of renal function.
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